Dimethyl Sulfoxide
Apexbio Technology LLC Apremilast (CC-10004) 608141-41-9 10mM (in 1mL DMSO)
Apremilast (CC-10004 CAS 608141-41-9) is a small-molecule inhibitor of phosphodiesterase 4 (PDE4) an enzyme involved in cyclic adenosine monophosphate (cAMP) hydrolysis and cytokine signaling pathways By competitively binding PDE4 s catalytic domain apremilast prevents intracellular cAMP degradation (IC50 0 074 M Ki 68 nM) thereby suppressing production of inflammatory mediators such as tumor necrosis factor- interleukin-23 CXCL9 and CXCL10 Due to these anti-inflammatory effects apremilast serves as a significant research tool in autoimmune conditions notably psoriasis and psoriatic arthritis
Apexbio Technology LLC Bortezomib (PS-341) 179324-69-7 10mM (in 1mL DMSO)
Bortezomib (PS-341 CAS number 179324-69-7) is a reversible proteasome inhibitor structurally composed as an N-terminally protected dipeptide (Pyz-Phe-boroLeu) containing pyrazinoic acid phenylalanine and leucine with boronic acid substitution It exerts biological activity primarily by inhibiting proteasomal degradation pathways thereby accumulating pro-apoptotic factors and initiating programmed cell death Bortezomib inhibits proliferation in cell-based assays such as human non-small cell lung cancer H460 cells (IC50 0 1 M) It has clinical approval for relapsed multiple myeloma and mantle cell lymphoma and is widely employed in research to study proteasome-regulated cellular processes and apoptosis signaling pathways
Apexbio Technology LLC Regorafenib 755037-03-7 10mM (in 1mL DMSO)
Regorafenib (CAS 755037-03-7) is an orally bioavailable inhibitor targeting multiple receptor tyrosine kinases (RTKs) such as VEGFR1/2/3 PDGFR Kit RET Raf-1 B-RAF and B-RAFV600E By impeding kinase phosphorylation (IC50 values ranging from approximately 1 5 46 nM) regorafenib disrupts signaling pathways associated with angiogenesis tumor cell proliferation and metastasis Preclinically regorafenib inhibited VEGFR2 phosphorylation (IC50 3 nM) and reduced VEGF-induced endothelial cell proliferation in vitro In rodent tumor xenograft models it demonstrated dose-dependent tumor growth suppression and antimetastatic potential supporting its utility for oncology research
Apexbio Technology LLC Lopinavir 192725-17-0 10mM (in 1mL DMSO)
Lopinavir is an inhibitor targeting the human immunodeficiency virus (HIV) protease enzyme implicated in viral polyprotein cleavage and maturation Structurally analogous to ritonavir lopinavir binds to HIV protease and suppresses catalytic activity consequently blocking HIV replication It demonstrates potent inhibitory actions against both wild-type and protease-inhibitor-resistant HIV variants Reported inhibition constants (Ki) for lopinavir range between 1 3 and 3 6 pM with antiviral efficacy represented by an EC50 below 0 06 M against protease mutants such as Val82 variants Due to its low susceptibility to inhibition by human serum proteins lopinavir is frequently utilized in antiviral screening assays drug-resistance research and investigations into HIV enzymology and resistance mechanisms
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 | C2H6OS | 1mL
Dimethyl sulfoxide (Standard) is the analytical standard of Dimethyl sulfoxide This product is intended for research and analytical applications Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves both polar and nonpolar compounds Dimethyl sulfoxide has anti-freezing and bacteriostatic properties[1][2]
Apexbio Technology LLC P005091 882257-11-6 10mM (in 1mL DMSO)
P005091 (CAS 882257-11-6) is an inhibitor that selectively targets the ubiquitin-specific protease 7 (USP7) also known as herpes-associated ubiquitin-specific protease (HAUSP) By blocking USP7-mediated deubiquitination P005091 promotes degradation of HDM2 resulting in altered regulation of downstream targets including increased cellular levels of tumor suppressor proteins p53 and p21 Through USP7 inhibition P005091 can downregulate claspin and suppress phosphorylation of DNA checkpoint kinase Chk1 enhancing genotoxic drug sensitivity and inducing apoptosis in cancer cell lines irrespective of p53 mutational status This makes P005091 relevant as a research probe for studying USP7-dependent signaling pathways and cancer cell biology
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 g/mol | C2H6OS | 10mL
Dimethyl sulfoxide (DMSO) meets analytical specification of Ch P is an aprotic solvent that dissolves polar and non-polar compounds including water-insoluble therapeutic and toxic agents Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties[1][2][3] br/ MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition) Amicrobic low endotoxin can be used in various biochemical experiments such as drug dissolution
Apexbio Technology LLC GMX1778 (CHS828) 200484-11-3 10mM (in 1mL DMSO)
GMX1778 (CHS828 CAS 200484-11-3) is a small-molecule inhibitor targeting nicotinamide phosphoribosyltransferase (NAMPT) an enzyme crucial for NAD biosynthesis with a reported Kd value of 120 nM NAD functions as a cofactor essential for enzymatic oxidation-reduction processes and diverse cellular events including metabolism genomic integrity calcium signaling aging and apoptosis In cultured IM-9 cells exposure to GMX1778 substantially decreases NAD and NM levels in a time-dependent manner GMX1778 displays anti-tumor activity preferentially in NAPRT1-deficient cancer models highlighting its potential utility for investigating metabolic vulnerabilities and targeted cancer therapies
Apexbio Technology LLC R406 841290-81-1 10mM (in 1mL DMSO)
R406 (CAS 841290-81-1) is an orally active inhibitor targeting spleen tyrosine kinase (SYK) a non-receptor tyrosine kinase prominently expressed in hematopoietic cells SYK mediates essential signaling upon activation of immune receptors including Fc and B-cell receptors impacting immune responses platelet activation osteoclast differentiation and vascular development By competitively binding to SYK s ATP-binding pocket R406 disrupts SYK-mediated downstream substrate phosphorylation It potently inhibits IgE- and IgG-induced Fc receptor signaling (IC50 56 64 nM) and blocks SYK-dependent B-cell receptor activation (SYK IC50 41 nM) inducing apoptosis in diffuse large B-cell lymphoma cell lines R406 is utilized in research investigating hematologic malignancies and immune-mediated disorders
Apexbio Technology LLC Alexidine dihydrochloride 1715-30-6 10mM (in 1mL DMSO)
Alexidine dihydrochloride is a selective inhibitor targeting mitochondrial protein tyrosine phosphatase 1 (PTPMT1) exhibiting inhibitory activity with an IC50 value of approximately 1 08 M in vitro By inhibiting PTPMT1 Alexidine dihydrochloride modulates mitochondrial signaling pathways implicated in cellular metabolism Additionally this compound enhances insulin secretion in pancreatic -cells of rat islet models In cancer biology research Alexidine dihydrochloride demonstrates activity against FaDu cells providing a relevant tool for studying mitochondrial phosphatase-mediated mechanisms in oncology and diabetes-related research applications
Apexbio Technology LLC Chlorpromazine HCl 69-09-0 10mM (in 1mL DMSO)
Chlorpromazine HCl (CAS 69-09-0) is a phenothiazine-based dopamine receptor antagonist with significant activity at G protein-coupled dopamine receptors in the central nervous system Mechanistically chlorpromazine directly binds to dopamine receptors competitively inhibiting receptor-ligand interactions as evidenced by its inhibition of [ H]spiperone binding in vitro In vivo studies indicate chronic chlorpromazine administration in rats induces behavioral sensitization and altered motor responses linked to DA and NMDA receptor function Clinically chlorpromazine is established as a conventional antipsychotic approved for schizophrenia treatment making it valuable in neuropharmacology research
Apexbio Technology LLC LY364947 396129-53-6 10mM (in 1mL DMSO)
LY364947 (CAS 396129-53-6) is a selective inhibitor targeting the kinase domain of transforming growth factor- (TGF- ) type I receptor TGF- signaling regulates crucial biological processes such as cell proliferation differentiation and tissue homeostasis In vitro studies demonstrated that LY364947 inhibits the receptor kinase activity with an IC50 of 51 nM effectively suppressing TGF- -dependent luciferase activity in mink lung epithelial cells (p3TP Lux assay) and growth of NIH 3T3 fibroblasts In vivo LY364947 showed protective effects against NMDA-induced retinal degeneration in rats attenuating retinal ganglion cell loss and capillary degradation Thus LY364947 serves as a valuable pharmacological tool in TGF- -related research and associated pathological conditions
Apexbio Technology LLC Acetaminophen 103-90-2 10mM (in 1mL DMSO)
Acetaminophen (paracetamol) is a cyclooxygenase-2 (COX-2) inhibitor widely employed in biomedical studies for investigating analgesic and antipyretic mechanisms Its inhibition of COX-2 enzyme activity occurs with an IC50 of approximately 25 8 M Experimental use includes inducing cellular hepatotoxicity models where acetaminophen exposure triggers glutathione depletion impaired glutathione peroxidase activity and ferroptosis-mediated cell death This makes acetaminophen useful in examining oxidative stress hepatic cell injury and associated cellular response mechanisms in vitro and in animal studies Additionally acetaminophen-mediated toxicity is applicable in screening protective agents or evaluating ferroptosis inhibitors in pharmacological research
Selleck Chemical LLC UBCS039, Solution 10mM (1mL in DMSO)
UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.
Selleck Chemical LLC OSS_128167, 10mM (1mL in DMSO)
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.